Monday, January 27, 2014

How Metalloproteinases (MMP-1) Damages the Skin

Metalloproteinases, also known as metalloprotease, matrixons or MMP is simply put, a degradation to collagen and elastin fibers, the main framework of skin cells.  The process of this aging of the skin is explained in the name, it is a protein enzyme that is involved with a metal.  Our bodies hold 23 MMP enzymes that help break down, one being MMP-1 or collagenase, which breaks down collagen.  We aquire the bad Metalloproteinases with unprotected sun exposure, and it is also found in sebum, a secretion in the sweat gland. (3)

Retinol, Ferulic acid, Vitamin C, Vitamin E, Kelp Extract, Phloretin, and Omega 3 acid ( eicosapentaenoic acid ),  and green tea have shown to inhibit and correct the effects of MMP-1.  Tissue inhibitors of metalloproteinases or TIMPs such as these are great for anti aging products.

One part of wound healing that doctors will look at is the level of MMP-1 to the level of TIMPs to figure out the healing process of a wound.  Patients with a high level of MMP-1 can have their wounds heal slowly or stop healing altogether.  Fibroblasts is a tissue that secretes collagen proteins that are the framework of connective tissue.(1)  Retinol is a key ingredient in resurrecting and maintaining fibroblasts in the skin to function in creating collagen. (2) Because of this, Fibroblasts are a major source of TIMPs

Products that Help TIMPs and inhibit Metalloproteinases

Retinol like SkinCeuticals Retinol 1.0, SkinCeuticals 0.5, Revision Retinol Repair
Vitamin C like SkinCeuticals CE Ferulic, SkinCeuticals Phloretin CF, Revision Vitamin C 30% Lotion



(1) http://ghr.nlm.nih.gov/glossary=fibroblast
(2) Proc. Natl. Acad. Sci. USA Vol. 94, pp. 10205–10208, September 1997 Cell Biology
(3) Journal of Investigative Dermatology, October 2005, pages 673–684

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